反应详情

4-Chloro-2-ethoxybenzoic acid ethyl ester (˜18 g) was suspended in ethanol (500 mL). This was treated with potassium hydroxide (200 mL, 2 M solution) and refluxed for 1 h. The reaction was cooled and poured into cold aqueous hydrochloric acid (300 mL, 3 M solution) and extracted into dichloromethane (3×500 mL). The dichloromethane was washed with water (500 mL) and dried over magnesium sulfate and evaporated to dryness to give 4-chloro-2-ethoxy-benzoic acid as a solid.

1. temperaturerefluxed for 1 h
2. temperatureThe reaction was cooled
3. extractionextracted into dichloromethane (3×500 mL)
4. washThe dichloromethane was washed with water (500 mL)
5. dry with materialdried over magnesium sulfate
6. customevaporated to dryness