Trimethylaluminum → rac-(4S,5R)-5-[4,5-Bis-(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl]-N-tert-butyl-2-chloro-4-ethoxybenzenesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	Trimethylaluminum	HCID 16682925	—
Reactant	rac-(4S,5R)-2-(4-tert-butyl-2-ethoxy-phenyl)-4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole	HCID 53628801	—
Reactant	5-Tert-butylsulfamoyl-4-chloro-2-ethoxybenzoic acid methyl ester	HCID 58894252	—
Product	rac-(4S,5R)-5-[4,5-Bis-(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl]-N-tert-butyl-2-chloro-4-ethoxybenzenesulfonamide	HCID 68683983	—

Reaction Steps

In a manner analogous to the method described in example 2, meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) was reacted with 5-tert-butylsulfamoyl-4-chloro-2-ethoxybenzoic acid methyl ester (example 43) in the presence of trimethylaluminum to give the title compound. HR-MS (ES, m/z) calculated for C29H33N3O3SCl3 [(M+H)+] 608.1303, observed 608.1300.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07851626B2
Source dataset	uspto-grants-2010_12
ORD ID	ord-be39ec07b7ab4ee6b0a7be1481119278
Source note	uspto-grants-2010_12