HRID2263927

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16682925

Aluminum, trimethyl-

C3H9Al

结构：CCOc1cc(C(C)(C)C)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1

HCID53628801

未命名化合物

结构：CCOc1cc(Cl)c(S(=O)(=O)NC(C)(C)C)cc1C(=O)OC

HCID58894252

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(Cl)c(S(=O)(=O)NC(C)(C)C)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1

HCID68683983

未命名化合物

PROCEDURE

实验过程

In a manner analogous to the method described in example 2, meso-2,3-bis-(4-chlorophenyl)-2,3-butanediamine (example 1) was reacted with 5-tert-butylsulfamoyl-4-chloro-2-ethoxybenzoic acid methyl ester (example 43) in the presence of trimethylaluminum to give the title compound. HR-MS (ES, m/z) calculated for C29H33N3O3SCl3 [(M+H)+] 608.1303, observed 608.1300.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-be39ec07b7ab4ee6b0a7be1481119278
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07851626B2
来源说明: uspto-grants-2010_12

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:34])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[NH:11]C(C3C=CC(C(C)(C)C)=CC=3OCC)=[N:9]2)=[CH:4][CH:3]=1.CO[C:37](=O)[C:38]1[CH:43]=[C:42]([S:44](=[O:51])(=[O:50])[NH:45][C:46]([CH3:49])([CH3:48])[CH3:47])[C:41]([Cl:52])=[CH:40][C:39]=1[O:53][CH2:54][CH3:55].C[Al](C)C>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:34])[C:12]([C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)([CH3:13])[NH:11][C:37]([C:38]3[C:39]([O:53][CH2:54][CH3:55])=[CH:40][C:41]([Cl:52])=[C:42]([S:44]([NH:45][C:46]([CH3:49])([CH3:48])[CH3:47])(=[O:51])=[O:50])[CH:43]=3)=[N:9]2)=[CH:4][CH:3]=1