HRID2263936

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6371

Phosgene

CCl2O

结构：CCOc1cc(Cl)c(S(=O)(=O)N2CCCC2)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1

HCID68683573

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(Cl)c(S(=O)(=O)N2CCCC2)cc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl

HCID72455736

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

In a manner analogous to the method described in example 3, rac-(4S*,5R*)-2-[4-chloro-2-ethoxy-5-(pyrrolidine-1-sulfonyl)phenyl]-4,5-bis-(4-chlorophenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazole (example 53) was reacted with phosgene in the presence of triethylamine to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-83792ce5145841e4a22d221ff1d9dc45
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07851626B2
来源说明: uspto-grants-2010_12

反应 SMILES

[Cl:1][C:2]1[C:7]([S:8]([N:11]2[CH2:15][CH2:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])=[CH:6][C:5]([C:16]2[NH:17][C:18]([C:30]3[CH:35]=[CH:34][C:33]([Cl:36])=[CH:32][CH:31]=3)([CH3:29])[C:19]([C:22]3[CH:27]=[CH:26][C:25]([Cl:28])=[CH:24][CH:23]=3)([CH3:21])[N:20]=2)=[C:4]([O:37][CH2:38][CH3:39])[CH:3]=1.[C:40](Cl)([Cl:42])=[O:41]>C(N(CC)CC)C>[Cl:1][C:2]1[C:7]([S:8]([N:11]2[CH2:12][CH2:13][CH2:14][CH2:15]2)(=[O:9])=[O:10])=[CH:6][C:5]([C:16]2[N:17]([C:40]([Cl:42])=[O:41])[C:18]([C:30]3[CH:31]=[CH:32][C:33]([Cl:36])=[CH:34][CH:35]=3)([CH3:29])[C:19]([C:22]3[CH:23]=[CH:24][C:25]([Cl:28])=[CH:26][CH:27]=3)([CH3:21])[N:20]=2)=[C:4]([O:37][CH2:38][CH3:39])[CH:3]=1