反应详情

2-Ethoxy-4-methoxybenzoic acid ethyl ester (13 g, 58 mmol) was suspended in ethanol (150 mL). This was treated with potassium hydroxide (40 mL, ˜4 M) and refluxed for 1 h. The reaction was cooled and poured into cold aqueous hydrochloric acid (300 mL, 2 M) and extracted into dichloromethane (3×200 mL). The organic layers were washed with brine and dried over anhydrous magnesium sulfate. The solids were filtered off, and the filtrate was evaporated to dryness to give 2-ethoxy-4-methoxybenzoic acid (9.5 g, white solid).

1. temperaturerefluxed for 1 h
2. temperatureThe reaction was cooled
3. extractionextracted into dichloromethane (3×200 mL)
4. washThe organic layers were washed with brine
5. dry with materialdried over anhydrous magnesium sulfate
6. filtrationThe solids were filtered off
7. customthe filtrate was evaporated to dryness