反应详情

温度

80 °C

2-Ethoxy-4-nitrobenzoic acid (20 g, 94 mmol, Aldrich) was suspended in ethanol (170 mL) and combined with a saturated aqueous solution of ammonium chloride (100 mL). As this was rapidly stirred, iron dust (13.3 g, 239 mmol) was added in portions. The temperature was raised to 80° C. for 1 h. The cooled suspension was filtered through Celite, and the cake washed with dichloromethane (150 mL). The filtrate was diluted with dichloromethane and washed with brine, dried over magnesium sulfate, filtered and evaporated. A brown solid was triturated with dichloromethane and filtered to give 15 g of 4-amino-2-ethoxybenzoic acid (88%).

1. filtrationThe cooled suspension was filtered through Celite
2. washthe cake washed with dichloromethane (150 mL)
3. additionThe filtrate was diluted with dichloromethane
4. washwashed with brine
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. customevaporated
8. customA brown solid was triturated with dichloromethane
9. filtrationfiltered