4'-[3-(3-Amidinophenyl)-3-tert-butoxycarbonyl-2-propylcarbazoylamino]-N-tert-butylbiphenyl-2-sulfonamide → 4'-[3-(3-Amidinophenyl)-2-propylcarbazoylamino]biphenyl-2-sulfonamide
Reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([N:10](C(OC(C)(C)C)=O)[N:11]([CH2:35][CH2:36][CH3:37])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[C:22]([S:27]([NH:30]C(C)(C)C)(=[O:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[NH:3])[NH2:2]>FC(F)(F)C(O)=O>[C:1]([C:4]1[CH:5]=[C:6]([NH:10][N:11]([CH2:35][CH2:36][CH3:37])[C:12]([NH:14][C:15]2[CH:20]=[CH:19][C:18]([C:21]3[C:22]([S:27]([NH2:30])(=[O:29])=[O:28])=[CH:23][CH:24]=[CH:25][CH:26]=3)=[CH:17][CH:16]=2)=[O:13])[CH:7]=[CH:8][CH:9]=1)(=[NH:2])[NH2:3]Participants
3
Procedure
0.5 g (0.803 mmol) of 408 is dissolved in 5.0 ml of trifluoroacetic acid and stirred at 5C for 18 h. After customary work-up, 0.15 g (99.3%) of 1 is thus obtained as crystals having a melting point of 215-216° C.; MS(FAB)=467.
Sources & evidence
- ORD record
- ord-921b97a7a421413380ed342cdcb67021
- Source dataset
- uspto-grants-2005_02
- Patent number
- US06849626B2
Reaction notes
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