Diethanolamine → HCID 68684273, compound

HRID 2264008Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:37])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[N:11]([C:21](Cl)=[O:22])[C:10]([C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][C:25]=3[O:34][CH2:35][CH3:36])=[N:9]2)=[CH:4][CH:3]=1.[OH:38][CH2:39][CH2:40][NH:41][CH2:42][CH2:43][OH:44]>>[OH:38][CH2:39][CH2:40][N:41]([CH2:42][CH2:43][OH:44])[C:21]([N:11]1[C:12]([C:14]2[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=2)([CH3:13])[C:8]([C:5]2[CH:6]=[CH:7][C:2]([Cl:1])=[CH:3][CH:4]=2)([CH3:37])[N:9]=[C:10]1[C:24]1[CH:29]=[CH:28][C:27]([C:30]([F:32])([F:33])[F:31])=[CH:26][C:25]=1[O:34][CH2:35][CH3:36])=[O:22]

Participants

Reactant 2

HCID 8113Diethanolamine

HCID 73408688rac-(4S*,5R*)-4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride

Product 1

HCID 68684273HCID 68684273, compound

Procedure

In a manner analogous to the method described in example 5, rac-(4S*,5R*)-4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-4-trifluoromethyl-phenyl)-4,5-dimethyl-4,5-dihydro-imidazole-1-carbonyl chloride was reacted with bis-(2-hydroxyethyl)-amine (Sigma) to give the title compound. HR-MS (ES, m/z) calculated for C31H33N3O4F3Cl2 [(M+H)+] 638.1795, observed 638.1797.

Sources & evidence

ORD record: ord-f370fefd992149ff80e61e139460b5a8
Source dataset: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07851626B2

Reaction notes

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