HRID2264013

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6371

Phosgene

CCl2O

结构：CCOc1cc(C(C)(C)C(C)=O)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1

HCID67071314

未命名化合物

PRODUCTS

生成物

结构：CCOc1cc(C(C)(C)C(C)=O)ccc1C1=NC(C)(c2ccc(Cl)cc2)C(C)(c2ccc(Cl)cc2)N1C(=O)Cl

HCID72455723

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8471

Triethylamine

C6H15N

PROCEDURE

实验过程

In a manner analogous to the method described in example 3, 3-{4-[4,5-bis-(4-chloro-phenyl)-4,5-dimethyl-4,5-dihydro-1H-imidazol-2-yl]-3-ethoxy-phenyl}-3-methyl-butan-2-one was reacted with phosgene in the presence of triethylamine to give the title compound.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d6cf4d2fae354ad09fd9017c157b94a8
来源数据集: uspto-grants-2010_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07851626B2
来源说明: uspto-grants-2010_12

反应 SMILES

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:36])[C:12]([C:14]3[CH:19]=[CH:18][C:17]([Cl:20])=[CH:16][CH:15]=3)([CH3:13])[NH:11][C:10]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([CH3:32])([CH3:31])[C:28](=[O:30])[CH3:29])=[CH:23][C:22]=3[O:33][CH2:34][CH3:35])=[N:9]2)=[CH:4][CH:3]=1.[C:37](Cl)([Cl:39])=[O:38]>C(N(CC)CC)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:36])[C:12]([C:14]3[CH:15]=[CH:16][C:17]([Cl:20])=[CH:18][CH:19]=3)([CH3:13])[N:11]([C:37]([Cl:39])=[O:38])[C:10]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([CH3:32])([CH3:31])[C:28](=[O:30])[CH3:29])=[CH:23][C:22]=3[O:33][CH2:34][CH3:35])=[N:9]2)=[CH:4][CH:3]=1