反应详情

1-(4-Chlorophenyl)propan-1-one (8.4 g, 50 mmol) was combined with hydroxylamine hydrochloride (4.0 g, 58 mmol), pyridine (4.6 g, 58 mmol), and ethanol (75 mL). The mixture was refluxed for 3 h. Solvent was evaporated and the residue diluted with water and extracted into diethyl ether/hexane (1:1). The organic extracts were washed with water, brine, and dried over anhydrous magnesium sulfate. Crystallization from cold hexane gave 5.0 g of 1-(4-chlorophenyl)propan-1-one oxime.

1. temperatureThe mixture was refluxed for 3 h
2. customSolvent was evaporated
3. additionthe residue diluted with water
4. extractionextracted into diethyl ether/hexane (1:1)
5. washThe organic extracts were washed with water, brine
6. dry with materialdried over anhydrous magnesium sulfate
7. customCrystallization from cold hexane