N-(tert-butyl)-2-iodo-6-methoxybenzenesulfonamide → 2-Iodo-6-methoxybenzenesulfonamide

HRID 2264126Notes

Reaction equation

HRID 2264126 reaction equation
C([NH:5][S:6]([C:9]1[C:14]([O:15][CH3:16])=[CH:13][CH:12]=[CH:11][C:10]=1[I:17])(=[O:8])=[O:7])(C)(C)C>FC(F)(F)C(O)=O>[I:17][C:10]1[CH:11]=[CH:12][CH:13]=[C:14]([O:15][CH3:16])[C:9]=1[S:6]([NH2:5])(=[O:8])=[O:7]

Participants

3

Reactant 1

HCID 23151662N-(tert-butyl)-2-iodo-6-methoxybenzenesulfonamide

Product 1

HCID 231507892-Iodo-6-methoxybenzenesulfonamide

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

42.40 g (114.84 mmol) N-(tert-butyl)-2-iodo-6-methoxybenzenesulfonamide are stirred in 265 ml of trifluoroacetic acid at room temperature for 3 h. Thereafter the reaction mixture is poured into ice-water and the precipitate is isolated by filtration and washed to neutrality with water. This gives 32.40 g (90% of theory) of 2-iodo-6-methoxybenzenesulfonamide.

Workup

  1. customthe precipitate is isolated by filtration
  2. washwashed

Sources & evidence

ORD record
ord-990ba9d0f7f94ce1810c0cf6a4f6fcc6
Source dataset
uspto-grants-2010_12
Patent number
US07855166B2

Reaction notes

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