反应详情

A solution of N-(6′-amino-3″-fluoro-3,2′:3′,4″-terpyridin-5′-yl)cyclopropanecarboxamide (0.2 g, 0.58 mmol) in acetic acid (2.5 mL) was heated in a sealed tube at 130° C. for 16 h. The solvent was evaporated and water (1 mL) was added and the solution was neutralised with 4% sodium bicarbonate aqueous solution and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4) and evaporated. The residue was purified by silica gel flash chromatography (100:8:1 dichloromethane/methanol/NH3) to give the title compound (0.024 g, 12% of yield).

1. customThe solvent was evaporated
2. additionwater (1 mL) was added
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with brine
5. dry with materialdried (MgSO4)
6. customevaporated
7. customThe residue was purified by silica gel flash chromatography (100:8:1 dichloromethane/methanol/NH3)