HCID 59595980, compound → HCID 178505986, compound

Participants

Reaction Steps

A solution of N-(6′-amino-3″-fluoro-3,2′:3′,4″-terpyridin-5′-yl)cyclopropanecarboxamide (0.2 g, 0.58 mmol) in acetic acid (2.5 mL) was heated in a sealed tube at 130° C. for 16 h. The solvent was evaporated and water (1 mL) was added and the solution was neutralised with 4% sodium bicarbonate aqueous solution and extracted with ethyl acetate. The organic layer was washed with brine, dried (MgSO4) and evaporated. The residue was purified by silica gel flash chromatography (100:8:1 dichloromethane/methanol/NH3) to give the title compound (0.024 g, 12% of yield).

Provenance & Evidence