Diisopropylethylamine → HCID 68787687, compound

Participants

Reaction Steps

A solution of 3-chloroisonicotinic acid (0.075 g, 0.48 mmol), N—[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate (0.178 g, 0.47 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.15 mL, 0.86 mmol) in DMF (1 mL) was stirred 15 minutes. Finally, 3″-fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1, 0.11 g, 0.39 mmol) in DMF (2.9 mL) was added and the mixture was stirred at room temperature 3.5 hours. The crude mixture was extracted between ethyl acetate and water. The organic layer was washed with water and brine, dried (MgSO4) and evaporated. The residue (0.195 g) was used in the next step without further purification.

Provenance & Evidence