Diisopropylethylamine → HCID 68787687, compound
Reaction equation
[Cl:1][C:2]1[CH:10]=[N:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=O.F[P-](F)(F)(F)(F)F.C[N:19](C(=[N+](C)C)ON1C2=NC=CC=C2N=N1)C.C(N(C(C)C)C(C)C)C.[F:44][C:45]1[CH:46]=[N:47][CH:48]=[CH:49][C:50]=1[C:51]1[C:52]([C:59]2[CH:60]=[N:61][CH:62]=[CH:63][CH:64]=2)=[N:53][C:54]([NH2:58])=[C:55](N)[CH:56]=1>CN(C=O)C>[NH2:58][C:54]1([NH:19][C:4](=[O:6])[C:3]2[CH:7]=[CH:8][N:9]=[CH:10][C:2]=2[Cl:1])[NH:53][C:52]([C:59]2[CH:60]=[N:61][CH:62]=[CH:63][CH:64]=2)=[C:51]([C:50]2[CH:49]=[CH:48][N:47]=[CH:46][C:45]=2[F:44])[CH:56]=[CH:55]1Participants
6
Reactant 4
Product 1
Reagents, catalysts & solvents 1
Procedure
A solution of 3-chloroisonicotinic acid (0.075 g, 0.48 mmol), N—[(dimethylamino)(3H-[1,2,3]triazolo[4,5-b]pyridin-3-yloxy)methylene]-N-methylmethanaminium hexafluorophosphate (0.178 g, 0.47 mmol) and N-ethyl-N-isopropylpropan-2-amine (0.15 mL, 0.86 mmol) in DMF (1 mL) was stirred 15 minutes. Finally, 3″-fluoro-3,2′:3′,4″-terpyridine-5′,6′-diamine (Intermediate 1, 0.11 g, 0.39 mmol) in DMF (2.9 mL) was added and the mixture was stirred at room temperature 3.5 hours. The crude mixture was extracted between ethyl acetate and water. The organic layer was washed with water and brine, dried (MgSO4) and evaporated. The residue (0.195 g) was used in the next step without further purification.
Workup
- extractionThe crude mixture was extracted between ethyl acetate and water
- washThe organic layer was washed with water and brine
- dry with materialdried (MgSO4)
- customevaporated
- customThe residue (0.195 g) was used in the next step without further purification
Sources & evidence
- ORD record
- ord-ab6d5a93499042cd942e142ef0017da9
- Source dataset
- uspto-grants-2010_12
- Patent number
- US07855202B2
Reaction notes
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