HCID 68790181, compound → HCID 178524347, compound

HRID 2264225Notes

Reaction equation

HRID 2264225 reaction equation
C([O:5][C:6](=[O:38])[C:7]1[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][C:15](=O)[NH:16][C:17]2[CH:18]=[C:19]([C:30]3[CH:35]=[CH:34][N:33]=[CH:32][C:31]=3[F:36])[C:20]([C:24]3[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=3)=[N:21][C:22]=2[NH2:23])=[CH:9][CH:8]=1)(C)(C)C>C(O)(=O)C>[F:36][C:31]1[CH:32]=[N:33][CH:34]=[CH:35][C:30]=1[C:19]1[CH:18]=[C:17]2[N:16]=[C:15]([CH2:14][CH2:13][C:10]3[CH:9]=[CH:8][C:7]([C:6]([OH:5])=[O:38])=[CH:12][CH:11]=3)[NH:23][C:22]2=[N:21][C:20]=1[C:24]1[CH:25]=[N:26][CH:27]=[CH:28][CH:29]=1

Participants

3

Reactant 1

HCID 68790181HCID 68790181, compound

Product 1

HCID 178524347HCID 178524347, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 4-[2-(6′-Amino-3″-fluoro-[3,2′;3′,4″]terpyridin-5′-ylcarbamoyl)-ethyl]-benzoic acid tert-butyl ester (0.135 g, 0.263 mmol) in acetic acid (2 mL) was heated in a sealed tube at 118° C. for 16 h. The solvent was evaporated and ethyl acetate was added. The solid formed was filtered and washed with 4% sodium bicarbonate aqueous solution, water and dried to give the title compound (0.08 g, 69% of yield).

Workup

  1. customThe solvent was evaporated
  2. additionethyl acetate was added
  3. customThe solid formed
  4. filtrationwas filtered
  5. washwashed with 4% sodium bicarbonate aqueous solution, water
  6. customdried

Sources & evidence

ORD record
ord-f968ea1bba7e46079aa7879e6f4f857f
Source dataset
uspto-grants-2010_12
Patent number
US07855202B2

Reaction notes

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