Aniline → HCID 16742558, compound

HRID 2264235Notes

Reaction equation

HRID 2264235 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C1(S([N:17]2[C:21]3=[N:22][CH:23]=[CH:24][CH:25]=[C:20]3[C:19]([C:26]3[CH:31]=[CH:30][N:29]=[C:28](Cl)[N:27]=3)=[CH:18]2)(=O)=O)C=CC=CC=1>>[C:2]1([NH:1][C:28]2[N:27]=[C:26]([C:19]3[C:20]4[C:21](=[N:22][CH:23]=[CH:24][CH:25]=4)[NH:17][CH:18]=3)[CH:31]=[CH:30][N:29]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 6115AnilineHCID 59596028HCID 59596028, compound

Product 1

HCID 16742558HCID 16742558, compoundYield 47%

Procedure

Using the procedure of example 1, aniline (83 mg) was reacted with compound 1f (100 mg) to provide compound 3 (36 mg, 47%). 1H NMR (400 MHz, CD3OD) δ 8.88 (d, J=7.8 Hz, 1H), 8.29 (t, J=6.0 Hz, 2H), 8.19 (s, 1H), 7.69 (d, J=7.8 Hz, 2H), 7.36 (t, J=7.6 Hz, 2H), 7.21 (m, 1H), 7.08 (t, J=7.8 Hz, 2H). MS (ESI) m/z: 288 (M+H)+.

Sources & evidence

ORD record
ord-8a8b01b19df04d3782ed0ce5f75e6734
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

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