Cycloheptylamine → HCID 58692202, compound

HRID 2264246Notes

Reaction equation

HRID 2264246 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1(S([N:18]2[C:22]3=[N:23][CH:24]=[CH:25][CH:26]=[C:21]3[C:20]([C:27]3[CH:32]=[CH:31][N:30]=[C:29](Cl)[N:28]=3)=[CH:19]2)(=O)=O)C=CC=CC=1>>[CH:1]1([NH:8][C:29]2[N:28]=[C:27]([C:20]3[C:21]4[C:22](=[N:23][CH:24]=[CH:25][CH:26]=4)[NH:18][CH:19]=3)[CH:32]=[CH:31][N:30]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2899CycloheptylamineHCID 59596028HCID 59596028, compound

Product 1

HCID 58692202HCID 58692202, compoundYield 41%

Procedure

Using the procedure of example 1, cycloheptylamine (92 mg) was reacted with compound 1f (100 mg) to provide compound 15 (34 mg, 41%). 1H NMR (400 MHz, CD3OD) δ 8.95 (d, J=8.0 Hz, 1H), 8.28 (d, J=4.8 Hz, 1H), 8.19 (s, 1H), 8.12 (d, J=5.6 Hz, 1H), 7.25 (dd, J=8.0 Hz, 4.8 Hz, 1H), 7.01 (d, J=5.6 Hz, 1H), 4.12 (m, 1H), 2.13 (m, 2H), 1.79-1.63 (m, 10H). MS (ESI) m/z: 308 (M+H)+.

Sources & evidence

ORD record
ord-9ccf1482665c4c6286ade8ebc4b4c8b7
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

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