2-Ethylaniline → HCID 44416063, compound

HRID 2264255Notes

Reaction equation

HRID 2264255 reaction equation
[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH2:5])[CH3:2].C1(S([N:19]2[C:23]3=[N:24][CH:25]=[CH:26][CH:27]=[C:22]3[C:21]([C:28]3[CH:33]=[CH:32][N:31]=[C:30](Cl)[N:29]=3)=[CH:20]2)(=O)=O)C=CC=CC=1>>[CH2:1]([C:3]1[CH:9]=[CH:8][CH:7]=[CH:6][C:4]=1[NH:5][C:30]1[N:29]=[C:28]([C:21]2[C:22]3[C:23](=[N:24][CH:25]=[CH:26][CH:27]=3)[NH:19][CH:20]=2)[CH:33]=[CH:32][N:31]=1)[CH3:2]

Participants

3

Reactant 2

HCID 113572-EthylanilineHCID 59596028HCID 59596028, compound

Product 1

HCID 44416063HCID 44416063, compoundYield 52%

Procedure

Using the procedure of example 1, 2-ethylaniline (98 mg) was reacted with compound 1f (100 mg) to provide compound 32 (44 mg, 52%). 1H NMR (400 MHz, CD3OD) δ 8.48 (d, J=8.0 Hz, 1H), 8.21-8.18 (m, 3H), 7.51 (d, J=7.2 Hz, 1H), 7.35 (d, J=7.2 Hz, 1H), 7.27 (m, 2H), 7.14 (d, J=5.2 Hz, 1H), 7.03 (dd, J=8.0 Hz, 4.8 Hz, 1H), 2.71 (q, J=7.6 Hz, 2H), 1.20 (t, J=7.6 Hz, 3H). MS (ESI) m/z: 316 (M+H)+.

Sources & evidence

ORD record
ord-cad62dd2559342d28f49a8f94a503d7f
Source dataset
uspto-grants-2010_12
Patent number
US07855205B2

Reaction notes

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