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HRID226428

反应详情

EQUATION

反应方程式

HRID 226428 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCOC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)c(Cl)c1.Cl.Cl
HCID86603632

未命名化合物

PRODUCTS

生成物

1
结构：CCOC(=O)/C=C/c1cnc(N[C@@H]2CCNC2)c(Cl)c1
HCID86603633

未命名化合物

收率 91.6%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

A solution of ethyl (2E)-3-{5-chloro-6-[(3R)-3-pyrrolidinylamino]-3-pyridinyl}acrylate dihydrochloride (2.0 g) in H2O (10 ml) was adjusted to pH 8.5 With 20% K2CO3 solution and extracted with CHCl3. The extract was dried over MgSO4, the solvent was evaporated in vacuo to give ethyl (2E)-3-{5-chloro-6-[(3R)-3-pyrrolidinylamino]-3-pyridinyl}acrylate (1.47 g).

WORKUP

后处理

  1. extractionextracted with CHCl3
  2. dry with materialThe extract was dried over MgSO4
  3. customthe solvent was evaporated in vacuo