Hydrochloric Acid → HCID 68658978, compound

HRID 2264312Notes

Reaction equation

HRID 2264312 reaction equation
[CH3:1][C:2]1[CH:36]=[C:5]2[N:6]=[CH:7][C:8]3[CH2:12][N:11]([C@@H:13]4[CH2:18][C@H:17]([NH:19]C(=O)OC(C)(C)C)[C@@H:16]([C:27]5[CH:32]=[C:31]([F:33])[C:30]([F:34])=[CH:29][C:28]=5[F:35])[CH2:15][CH2:14]4)[CH2:10][C:9]=3[N:4]2[N:3]=1.[ClH:37]>>[ClH:37].[ClH:37].[CH3:1][C:2]1[CH:36]=[C:5]2[N:6]=[CH:7][C:8]3[CH2:12][N:11]([C@@H:13]4[CH2:18][C@H:17]([NH2:19])[C@@H:16]([C:27]5[CH:32]=[C:31]([F:33])[C:30]([F:34])=[CH:29][C:28]=5[F:35])[CH2:15][CH2:14]4)[CH2:10][C:9]=3[N:4]2[N:3]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86639711HCID 86639711, compound

Product 1

HCID 68658978HCID 68658978, compound

Procedure

To the more polar product from Step A was added 1 mL of hydrochloric acid (4.0 M in 1,4-dioxane) and the solution was stirred for 30 min and the solvent evaporated in vacuo to afford the title compound as a white solid. LC/MS 402.1 (M+1).

Workup

  1. customthe solvent evaporated in vacuo

Sources & evidence

ORD record
ord-ce549af5bea24ebda21dc5bc0bcc6dea
Source dataset
uspto-grants-2010_12
Patent number
US07855206B2

Reaction notes

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