反应详情

In 70 ml of toluene was dissolved 3.2 g of ethyl 4-formyl-3-nitrobenzoate and then 5.75 g of methyl triphenylphosphoranylideneacetate, followed by 6 hours of stirring under reflux. After cooling, the reaction solution was concentrated under reduced pressure and the obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate) to obtain 3.63 g of ethyl 4-[(1E)-3-methoxy-3-oxoprop-1-en-1-yl]-3-nitrobenzoate as a white solid.

1. temperatureunder reflux
2. temperatureAfter cooling
3. concentrationthe reaction solution was concentrated under reduced pressure
4. customthe obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate)