HCID 59376682, compound → HCID 68646516, compound

HRID 2264356Notes

Reaction equation

HRID 2264356 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:13][CH:12]=[C:11]([C:14]2[C:15]([CH3:21])=[N:16][C:17]([NH2:20])=[CH:18][CH:19]=2)[CH2:10][CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd].CO>[C:1]([O:5][C:6]([N:8]1[CH2:9][CH2:10][CH:11]([C:14]2[C:15]([CH3:21])=[N:16][C:17]([NH2:20])=[CH:18][CH:19]=2)[CH2:12][CH2:13]1)=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 1

HCID 59376682HCID 59376682, compound

Product 1

HCID 68646516HCID 68646516, compoundYield 97%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Stir a mixture of 6-amino-2-methyl-3′,6′-dihydro-2′H-[3,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (2.12 g) and palladium on carbon 10% wet (330 mg) in methanol (29.30 mL) under H2 (45 psi) for 48 h. Filtered over a celite pad and remove the solvent under vacuum to afford 2.07 g of the title compound. MS (ES+): m/z=292 (M+H)+.

Workup

  1. filtrationFiltered over a celite pad
  2. customremove the solvent under vacuum

Sources & evidence

ORD record
ord-81d2b4439e914052b0d6870e37b07706
Source dataset
uspto-grants-2010_12
Patent number
US07855211B2

Reaction notes

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