Hydrogen Bromide → HCID 68778597, compound

Participants

Reaction Steps

A solution of 4-(pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.07 g, 4.28 mmol) in 48% HBr in water (60 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrobromide salt. MS (ISP): 179.3 [M+H]+.

Provenance & Evidence