Hydrogen Bromide → HCID 68778597, compound

HRID 2264418Notes

Reaction equation

HRID 2264418 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[N:18]=[CH:17][CH:16]=[CH:15][N:14]=2)[CH2:8][CH2:7]1)=O)C.[BrH:19]>O>[BrH:19].[BrH:19].[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[N:14]=[CH:15][CH:16]=[CH:17][N:18]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 260Hydrogen BromideHCID 21475314HCID 21475314, compound

Product 1

HCID 68778597HCID 68778597, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of 4-(pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.07 g, 4.28 mmol) in 48% HBr in water (60 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrobromide salt. MS (ISP): 179.3 [M+H]+.

Workup

  1. temperatureto reflux for 18 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-0742a0d701934df3bdbcdd698bda036f
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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