反应详情

A solution of 2-(1-tert-butoxycarbonyl-piperidin-4-ylamino)-pyrimidine-4-carboxylic acid methyl ester (0.48 g, 1.43 mmol) in ethanol (10 mL) and 4 M HCl in dioxane (10 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 237.4 [M+H]+.

1. customThe solvent was removed under reduced pressure
2. customthe crude product used in the consecutive step without further purification