Hydrochloric Acid → 2-Pyrimidinamine, N-4-piperidinyl-4-(trifluoromethyl)-, hydrochloride (1:2)

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Reaction Steps

A solution of 4-(4-trifluoromethyl-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.47 g, 10.02 mmol) in ethanol (50 mL) and 4 M HCl in dioxane (75 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 247.1 [M+H]+.

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