Hydrochloric Acid → 2-Pyrimidinamine, N-4-piperidinyl-4-(trifluoromethyl)-, hydrochloride (1:2)

HRID 2264423Notes

Reaction equation

HRID 2264423 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:25]>C(O)C.O1CCOCC1>[ClH:25].[ClH:25].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[CH:18]=[CH:17][N:16]=2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68781393HCID 68781393, compound

Product 1

HCID 687813762-Pyrimidinamine, N-4-piperidinyl-4-(trifluoromethyl)-, hydrochloride (1:2)

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4-trifluoromethyl-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.47 g, 10.02 mmol) in ethanol (50 mL) and 4 M HCl in dioxane (75 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 247.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-7c0fb764aafb401ca55ca919e1958401
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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