HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 178478869, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ethyl 4-[(4-methoxy-2-pyrimidinyl)amino]-1-piperidinecarboxylate | HCID 24237580 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | HCID 178478869 | HCID 178478869 | — |
Reaction Steps
A solution of 4-(4-methoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.5 g, 5.35 mmol) in ethanol (50 mL) and conc. HCl (75 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 194.9 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855194B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-c15ad42c7ced438db05870c50bbf275b |
| Source note | uspto-grants-2010_12 |