Hydrochloric Acid → HCID 178478869, compound

HRID 2264425Notes

Reaction equation

HRID 2264425 reaction equation
C(OC([N:6]1[CH2:11][CH2:10][CH:9]([NH:12][C:13]2[N:18]=[C:17]([O:19]C)[CH:16]=[CH:15][N:14]=2)[CH2:8][CH2:7]1)=O)C.[ClH:21]>C(O)C>[ClH:21].[ClH:21].[NH:6]1[CH2:7][CH2:8][CH:9]([NH:12][C:13]2[N:18]=[C:17]([OH:19])[CH:16]=[CH:15][N:14]=2)[CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 24237580Ethyl 4-[(4-methoxy-2-pyrimidinyl)amino]-1-piperidinecarboxylate

Product 1

HCID 178478869HCID 178478869, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 4-(4-methoxy-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid ethyl ester (1.5 g, 5.35 mmol) in ethanol (50 mL) and conc. HCl (75 mL) was heated to reflux for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 194.9 [M+H]+.

Workup

  1. temperatureto reflux for 18 h
  2. customThe solvent was removed under reduced pressure
  3. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-c15ad42c7ced438db05870c50bbf275b
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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