Hydrochloric Acid → HCID 68779481, compound

Participants

Reaction Steps

To a suspension of 4-(4-amino-5-cyano-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.02 g, 9.49 mmol) in dioxane (10 mL) and THF (10 mL) was added 4 M HCl in dioxane (50 mL) and the reaction mixture stirred at rt for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 219.1 [M+H]+.

Provenance & Evidence