Hydrochloric Acid → HCID 68779481, compound

HRID 2264434Notes

Reaction equation

HRID 2264434 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([NH2:21])[C:18]([C:22]#[N:23])=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:24]>O1CCOCC1.C1COCC1>[ClH:24].[ClH:24].[NH2:21][C:19]1[C:18]([C:22]#[N:23])=[CH:17][N:16]=[C:15]([NH:14][CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:20]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68781993HCID 68781993, compound

Product 1

HCID 68779481HCID 68779481, compound

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolventHCID 312751,4-DioxaneSolvent2×

Procedure

To a suspension of 4-(4-amino-5-cyano-pyrimidin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (3.02 g, 9.49 mmol) in dioxane (10 mL) and THF (10 mL) was added 4 M HCl in dioxane (50 mL) and the reaction mixture stirred at rt for 18 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 219.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-26473ba42ddb41dfbfb32a0fa4aa8c00
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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