Hydrochloric Acid → HCID 68782020, compound

Participants

Reaction Steps

A solution of 4-[5-(4-carbamoyl-phenyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.31 g, 0.78 mmol) in 4 M HCl in dioxane (40 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 298.4 [M+H]+.

Provenance & Evidence