Hydrochloric Acid → HCID 68782020, compound

HRID 2264443Notes

Reaction equation

HRID 2264443 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[CH:19][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27](=[O:29])[NH2:28])=[CH:23][CH:22]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30]>O1CCOCC1>[ClH:30].[ClH:30].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:16]=[CH:17][C:18]([C:21]3[CH:26]=[CH:25][C:24]([C:27]([NH2:28])=[O:29])=[CH:23][CH:22]=3)=[CH:19][N:20]=2)[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68781301HCID 68781301, compound

Product 1

HCID 68782020HCID 68782020, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[5-(4-carbamoyl-phenyl)-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.31 g, 0.78 mmol) in 4 M HCl in dioxane (40 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 298.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-27a05b929a25482dbfd05f06a04c9830
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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