HCID 68778603, compound → HCID 86615294, compound

HRID 2264445Notes

Reaction equation

HRID 2264445 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[C:18]([C:25](=[O:34])[NH:26][C:27]3[CH:32]=[CH:31][C:30]([Cl:33])=[CH:29][CH:28]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C>Cl.O1CCOCC1>[ClH:33].[ClH:33].[Cl:33][C:30]1[CH:31]=[CH:32][C:27]([NH:26][C:25]([C:18]2[C:19]([C:21]([F:22])([F:23])[F:24])=[N:20][C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:16][CH:17]=2)=[O:34])=[CH:28][CH:29]=1

Participants

4

Reactant 1

HCID 68778603HCID 68778603, compound

Product 1

HCID 86615294HCID 86615294, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[5-(4-chloro-phenylcarbamoyl)-4-trifluoromethyl-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (1.0 g, 2.00 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 400.1 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-8be02313e1d640ef8e9d16cb46bf2284
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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