Hydrochloric Acid → HCID 86615296, compound

HRID 2264447Notes

Reaction equation

HRID 2264447 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[C:19]([C:21]([F:24])([F:23])[F:22])[C:18]([C:25](=[O:38])[NH:26][C:27]3[CH:32]=[CH:31][C:30]([O:33][C:34]([F:37])([F:36])[F:35])=[CH:29][CH:28]=3)=[CH:17][N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:39]>O1CCOCC1>[ClH:39].[ClH:39].[F:37][C:34]([F:35])([F:36])[O:33][C:30]1[CH:31]=[CH:32][C:27]([NH:26][C:25]([C:18]2[C:19]([C:21]([F:22])([F:23])[F:24])=[N:20][C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)=[N:16][CH:17]=2)=[O:38])=[CH:28][CH:29]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86615295HCID 86615295, compound

Product 1

HCID 86615296HCID 86615296, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-[5-(4-trifluoromethoxy-phenylcarbamoyl)-4-trifluoromethyl-pyrimidin-2-ylamino]-piperidine-1-carboxylic acid tert-butyl ester (0.92 g, 1.67 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 450.3 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-7cfe3b46adff4c68aa44e8ff2180759b
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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