Hydrochloric Acid → Piperidin-4-yl-(4,6,7-trimethoxy-quinazolin-2-yl)-amine dihydrochloride

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Reaction Steps

A solution of 4-(4,6,7-trimethoxy-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.2 g, 0.48 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ESI): 319.4 [M+H]+.

Provenance & Evidence