Hydrochloric Acid → Piperidin-4-yl-(4,6,7-trimethoxy-quinazolin-2-yl)-amine dihydrochloride

HRID 2264449Notes

Reaction equation

HRID 2264449 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([O:25][CH3:26])[C:22]3[C:17](=[CH:18][C:19]([O:29][CH3:30])=[C:20]([O:27][CH3:28])[CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>C(O)C.O1CCOCC1>[ClH:31].[ClH:31].[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([O:25][CH3:26])[C:22]3[C:17](=[CH:18][C:19]([O:29][CH3:30])=[C:20]([O:27][CH3:28])[CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 687835484-(4,6,7-Trimethoxy-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester

Product 1

HCID 68782047Piperidin-4-yl-(4,6,7-trimethoxy-quinazolin-2-yl)-amine dihydrochloride

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4,6,7-trimethoxy-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.2 g, 0.48 mmol) in ethanol (5 mL) and 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ESI): 319.4 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-6418f0cc24334c71b6d13f09ca5e9e49
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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