Hydrochloric Acid → HCID 68780195, compound

Participants

Reaction Steps

A solution of 4-(6,7-dimethoxy-4-morpholin-4-yl-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (2.45 g, 5.18 mmol) in ethanol (10 mL) and 4 M HCl in dioxane (40 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 374.3 [M+H]+.

Provenance & Evidence