Hydrochloric Acid → HCID 68780195, compound

HRID 2264461Notes

Reaction equation

HRID 2264461 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([N:25]3[CH2:30][CH2:29][O:28][CH2:27][CH2:26]3)[C:22]3[C:17](=[CH:18][C:19]([O:33][CH3:34])=[C:20]([O:31][CH3:32])[CH:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:35]>C(O)C.O1CCOCC1>[ClH:35].[ClH:35].[CH3:32][O:31][C:20]1[CH:21]=[C:22]2[C:17](=[CH:18][C:19]=1[O:33][CH3:34])[N:16]=[C:15]([NH:14][CH:11]1[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)[N:24]=[C:23]2[N:25]1[CH2:26][CH2:27][O:28][CH2:29][CH2:30]1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 68780154HCID 68780154, compound

Product 1

HCID 68780195HCID 68780195, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(6,7-dimethoxy-4-morpholin-4-yl-quinazolin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (2.45 g, 5.18 mmol) in ethanol (10 mL) and 4 M HCl in dioxane (40 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 374.3 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-8758b9a70b6a4c6b9e608066fe74f91f
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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