Hydrochloric Acid → HCID 68779388, compound

HRID 2264463Notes

Reaction equation

HRID 2264463 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:24]=[C:23]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:22]3[C:17](=[N:18][CH:19]=[CH:20][N:21]=3)[N:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>O1CCOCC1>[ClH:31].[ClH:31].[C:25]1([C:23]2[C:22]3[C:17](=[N:18][CH:19]=[CH:20][N:21]=3)[N:16]=[C:15]([NH:14][CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[N:24]=2)[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 68779242HCID 68779242, compound

Product 1

HCID 68779388HCID 68779388, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of 4-(4-phenyl-pteridin-2-ylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.5 g, 1.23 mmol) in 4 M HCl in dioxane (20 mL) was stirred at rt for 2 h. The solvent was removed under reduced pressure and the crude product used in the consecutive step without further purification assuming quantitative deprotection and formation of the dihydrochloride salt. MS (ISP): 307.5 [M+H]+.

Workup

  1. customThe solvent was removed under reduced pressure
  2. customthe crude product used in the consecutive step without further purification

Sources & evidence

ORD record
ord-db53959b6ac844b781e19664baab81e4
Source dataset
uspto-grants-2010_12
Patent number
US07855194B2

Reaction notes

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