Water → HCID 10200870, compound

HRID 2264518Notes

Reaction equation

HRID 2264518 reaction equation
Cl[C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[N:3]=1.[CH2:29]([NH2:31])[CH3:30].O>C1COCC1>[CH2:29]([NH:31][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:18]=[CH:17][C:13]3[O:14][CH2:15][O:16][C:12]=3[CH:11]=2)[C:5]([C:19]#[N:20])=[C:4]([O:21][CH2:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[N:3]=1)[CH3:30]

Participants

5

Reactant 3

HCID 962WaterHCID 6341EthylamineHCID 17976006HCID 17976006, compound

Product 1

HCID 10200870HCID 10200870, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

30 mg (0.08 mmol) of 2-chloro-4-(1,3-benzodioxol-5-yl)-6-benzyloxy-3,5-pyridinedicarbonitrile (example 4, step 1) and 10.4 mg (0.23 mmol) of ethylamine are shaken together in 0.12 ml of THF for about 16 h. Water is added to the reaction solution and the product that crystallizes out is filtered off with suction and dried under reduced pressure.

Workup

  1. customthe product that crystallizes out
  2. filtrationis filtered off with suction
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-cd5bf17a7b824c9a8f74ee4f29d801d6
Source dataset
uspto-grants-2010_12
Patent number
US07855219B2

Reaction notes

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