Piconol → HCID 9901909, compound

HRID 2264520Notes

Reaction equation

HRID 2264520 reaction equation
[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]([C:16]#[N:17])=[C:4](Cl)[N:3]=1.CC(C)([O-])C.[K+].[OH:25][CH2:26][C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=1>>[NH2:1][C:2]1[C:7]([C:8]#[N:9])=[C:6]([C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)[C:5]([C:16]#[N:17])=[C:4]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[N:3]=1

Participants

4

Reactant 3

HCID 11474PiconolHCID 27867132-amino-6-chloro-4-phenylpyridine-3,5-dicarbonitrileHCID 23665647Potassium tert-butoxide

Product 1

HCID 9901909HCID 9901909, compound

Conditions

Temperature
60 °C

Procedure

102 mg (0.4 mmol) of 2-amino-6-chloro-4-phenyl-3,5-pyridinedicarbonitrile [Quintela et al., Heterocycles 38, 1299-1305 (1994)] and 54 mg (0.48 mmol) of potassium tert-butoxide are dissolved together in 1.696 g (=1.5 ml, 15.55 mmol) of 2-hydroxymethylpyridine, and the mixture is stirred at 60° C. for about 16 h. The product which crystallizes out is filtered off with suction, washed with water and dried under reduced pressure.

Workup

  1. customThe product which crystallizes out
  2. filtrationis filtered off with suction
  3. washwashed with water
  4. customdried under reduced pressure

Sources & evidence

ORD record
ord-ffe602e17e554fb88ee0e841d16fd830
Source dataset
uspto-grants-2010_12
Patent number
US07855219B2

Reaction notes

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