HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Hydroxyquinoline → 6-(6-Chloropyrimidin-4-yloxy)quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Hydroxyquinoline | HCID 11374 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 4,6-Dichloropyrimidine | HCID 70943 | — |
| Solvent | Propan-2-one--water (1/1) | HCID 18366337 | — |
| Product | 6-(6-Chloropyrimidin-4-yloxy)quinoline | HCID 57600084 | — |
Reaction Steps
A solution of 7.45 g (50 mMol) of 4,6-dichlor-pyrimidine, 7.64 g (50 mMol) of 6-hydroxy-chinolin and 2.0 g (50 mMol) NaOH dissolved in 200 ml of H2O/acetone 1:1 is stirred for 3 h. The resulting solid is filtered off, washed with H2O/acetone ans dried: m.p.: 136-137° C.; MS: [M+1]+=258.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07855215B2 |
| Source dataset | uspto-grants-2010_12 |
| ORD ID | ord-61fc11e1f7434d909c5b74ea45bc281c |
| Source note | uspto-grants-2010_12 |