HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2264566Generated: November 2, 2026
Sodium Azide → 6-Azido-4-(quinolin-6-yloxy)-pyrimidine
https://huagongshe.com/reaction/2264566
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 6-(6-Chloropyrimidin-4-yloxy)quinoline | HCID 57600084 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 6-Azido-4-(quinolin-6-yloxy)-pyrimidine | HCID 86234638 | — |
Reaction Steps
To a solution of 9.4 g (36.4 mMol) of 6-chloro-4-(quinolin-6-yloxy)-pyrimidine in 110 ml DMF, 4.74 g (73 mMol) NaN3 are added. After stirring for 60 min at 60° C., the solution is diluted with EtOAc and water. The aqueous layer is separated off and extracted 2× with EtOAc. The organic phases are washed with water and brine, dried (Na2SO4) and concentrate in vacuo to give the crude title compound which is used as such in the next step: MS: [M+1]+=265.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07855215B2 |
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| Source dataset | uspto-grants-2010_12 |
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| ORD ID | ord-09cd8d930764423eb407ad7bcf53dc3d |
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| Source note | uspto-grants-2010_12 |
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