反应详情

温度

60 °C

To a solution of 9.4 g (36.4 mMol) of 6-chloro-4-(quinolin-6-yloxy)-pyrimidine in 110 ml DMF, 4.74 g (73 mMol) NaN3 are added. After stirring for 60 min at 60° C., the solution is diluted with EtOAc and water. The aqueous layer is separated off and extracted 2× with EtOAc. The organic phases are washed with water and brine, dried (Na2SO4) and concentrate in vacuo to give the crude title compound which is used as such in the next step: MS: [M+1]+=265.

1. customThe aqueous layer is separated off
2. extractionextracted 2× with EtOAc
3. washThe organic phases are washed with water and brine
4. dry with materialdried (Na2SO4)
5. concentrationconcentrate in vacuo