Hydrochloric Acid → HCID 86603780, compound

HRID 226472Notes

Reaction equation

HRID 226472 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([NH:25][O:26]C3CCCCO3)=[O:24])=[CH:17][C:16]=2[Cl:33])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34]>CCO.CO>[ClH:33].[ClH:34].[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]2[N:20]=[CH:19][C:18](/[CH:21]=[CH:22]/[C:23]([NH:25][OH:26])=[O:24])=[CH:17][C:16]=2[Cl:33])[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86603782HCID 86603782, compound

Product 1

HCID 86603780HCID 86603780, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 887MethanolSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of (2E)-3-{6-[(1-benzyl-4-piperidyl)amino]-5-chloro-3-pyridyl}-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide(168 mg) in EtOH(2 ml) was treated with 10% HCl in MeOH (1.76 ml) and was stirred at 25° C. for 1 hour. The precipitate was collected, washed with EtOH, dried under reduced pressure to give (2E)-3-{6-[(1-benzyl-4-piperidyl)amino]-5-chloro-3-pyridyl}-N-hydroxyacrylamide dihydrochloride (137 mg).

Workup

  1. customThe precipitate was collected
  2. washwashed with EtOH
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-af18a4ed799344a7be969310e7e26340
Source dataset
uspto-grants-2009_07
Patent number
US07557127B2

Reaction notes

Loading…