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HRID2264817

反应详情

EQUATION

反应方程式

HRID 2264817 的结构方程式

REACTANTS

反应物

1
结构：COC(=O)[C@@H](N)CC#Cc1ccc(NCc2ccccc2F)cc1
HCID59596671

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@@H]1CCC(c2ccc(NCc3ccccc3F)cc2)=N1
HCID59596710

未命名化合物

收率 29.5%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O=S(=O)([O-])C(F)(F)F.[Ag+]
催化剂HCID76223

Methanesulfonic acid, trifluoro-, silver(1+) salt

CAgF3O3S

PROCEDURE

实验过程

A solution of methyl (2S)-2-amino-5-(4-{[(2-fluorophenyl)methyl]amino}phenyl)-4-pentynoate (D66, 132 mg) and silver triflate (11 mg, 0.045 mmol) was stirred at room temperature 6.5 h. Then silica gel was added and the solvent evaporated. The residue was purified using flash chromatography eluting with a cyclohexanes:ethyl acetate gradient (12%-100%) to afford the title compound (39 mg, 26%). MS: (ES/+) m/z: 327 [MH]+, C19H19FN2O2 requires 326.

WORKUP

后处理

  1. additionThen silica gel was added
  2. customthe solvent evaporated
  3. customThe residue was purified
  4. washeluting with a cyclohexanes