Hydrochloric Acid → HCID 136335099, compound

HRID 226482Notes

Reaction equation

HRID 226482 reaction equation
[CH3:1][C:2]1[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11]2[N:12]=[CH:13][C:14](/[CH:17]=[CH:18]/[C:19]([NH:21][O:22]C3CCCCO3)=[O:20])=[N:15][CH:16]=2)[CH2:6]1.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[CH3:1][C:2]1[C:32]([CH3:33])=[CH:31][CH:30]=[CH:29][C:3]=1[CH2:4][N:5]1[CH2:9][CH2:8][C@@H:7]([NH:10][C:11]2[N:12]=[CH:13][C:14](/[CH:17]=[CH:18]/[C:19]([NH:21][OH:22])=[O:20])=[N:15][CH:16]=2)[CH2:6]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86603808HCID 86603808, compound

Product 1

HCID 136335099HCID 136335099, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

To a solution of (2E)-3-(5-{[(3R)-1-(2,3-dimethylbenzyl)-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (46 mg) in ethanol (1 mL) was added 2N hydrogen chloride in ethanol (0.26 mL). After stirring at room temperature for 2 hours, the reaction mixture was evaporated in vacuo and triturated with ethyl acetate to give (2E)-3-(5-{[(3R)-1-(2,3-dimethylbenzyl)-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-hydroxyacrylamide dihydrochloride (31 mg).

Workup

  1. customthe reaction mixture was evaporated in vacuo
  2. customtriturated with ethyl acetate

Sources & evidence

ORD record
ord-37e4b02f4ff14d4c9cce6718f1e09bab
Source dataset
uspto-grants-2009_07
Patent number
US07557127B2

Reaction notes

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