反应详情

TFA (3 ml) was added dropwise to a solution of 1,1-dimethylethyl {2-oxo-2-[(phenylmethyl)(2-propen-1-yl)amino]ethyl}(phenylmethyl)carbamate (D89, 1.18 g, 3 mmol) in dry dichloromethane (12 ml) at 0° C. After stirring at room temperature for 3 h the solvent was evaporated and the residue purified via SCX cartridge to give the title compound (880 mg, quant.) as a clear oil. 1H NMR (400 MHz, CDCl3) δ (ppm): 7.4-7.2 (m, 10H), 5.9-5.6 (m, 1H), 5.2-5.0 (m, 2H), 4.6, 4.4 (s, 2H), 4.1-3.7 (m, 4H), 3.5 (s, 2H), 2.4 (bs, 1H).

1. customwas evaporated
2. customthe residue purified via SCX cartridge